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| Mechanisms of schizophrenia ： ウィキペディア英語版 |
Mechanisms of schizophrenia
The underlying mechanisms of schizophrenia, a mental disorder characterized by a disintegration of the processes of thinking and of emotional responsiveness, are complex. A number of theories attempt to explain the link between altered brain function and schizophrenia, the most important of which are the dopamine hypothesis and the glutamate hypothesis. Note that these theories are separate from the causes of schizophrenia, which deal with actual starting points of the illness instead, e.g. genetic and environmental factors. The current theories attempt to explain how changes in brain functioning can contribute to symptoms of the disease.
== Pathophysiology ==
The exact pathophysiology of schizophrenia remains poorly understood. Since the coining of schizophrenia by Eugene Bleuler in 1908, quite a variety of theories have been proposed concerning its underlying pathophysiology. The most commonly supported theories are the dopamine hypothesis and the glutamate hypothesis. More recent theories evolve around specific dysfunction of interneurons, abnormalities in the immune system, and oxidative stress.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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